A study by the MCTP research team, led by Dr. Ram Shankar, has discovered that androgen signaling induces changes in chromosomal proximity, causing the co-localization of the TMPRSS2 and ERG genes and increases the likelihood that they will fuse to produce the TMPRSS2-ERG fusion, found in 50% of prostate cancer cases.  This discovery sheds new light on the possible early events of prostate cancer development, the details of which appear in Science.

For more information on this discovery, members of the general public, news media, and scientific communities may click here to read our "Latest From The Bench" page on this topic and obtain a pdf of the original research submission from Science.

Click here to view the UMHS press release regarding this discovery.

Click here to read the story about this discovery in the NCI Cancer Bulletin and  Medical News Today.

To view more discoveries from MCTP, please click here to view our Latest From the Bench topics.

       Dr. Ram Shankar, MCTP Research Fellow